Brimonidine and Timolol
Combigan is a prescription eye drop medication that combines two active ingredients to lower intraocular pressure in patients with glaucoma or ocular hypertension. It is used when a single medication is insufficient to control eye pressure, helping to prevent optic nerve damage and vision loss.
Combigan is an eye drop that lowers eye pressure in glaucoma patients using a dual-mechanism combination of brimonidine and timolol.
Key facts at a glance
- RxNorm
- 746962
- Generic
- Combigan
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Combigan is indicated for the reduction of elevated intraocular pressure in patients with glaucoma or ocular hypertension who require additional IOP control beyond single-agent therapy.
Combigan combines two active ingredients: brimonidine (an alpha-2 agonist) which reduces fluid production and increases drainage from the eye, and timolol (a beta-blocker) which decreases aqueous humor production, resulting in lowered eye pressure.
Combigan is for topical ophthalmic use only. It is contraindicated in patients with asthma, severe COPD, certain heart conditions, or those taking MAO inhibitors. Common side effects include eye redness, burning, itching, and dry mouth. Patients should remove contact lenses before use and wait 15 minutes before reinserting. Systemic absorption may cause effects similar to oral beta-blockers.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy