Estradiol and Norethindrone
Combipatch is a transdermal hormone replacement therapy (HRT) medication that delivers a combination of estrogen and progestin through the skin via a twice-weekly patch. It is primarily prescribed to women experiencing symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. The medication also helps prevent osteoporosis in postmenopausal women.
Combipatch is a hormone replacement patch containing estrogen and progestin used to treat menopausal symptoms and prevent osteoporosis in postmenopausal women.
Key facts at a glance
- RxNorm
- 216161
- Generic
- Combipatch
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Combipatch is used to treat moderate to severe vasomotor symptoms (hot flashes, night sweats) associated with menopause. It is also prescribed for the treatment of vulvar and vaginal atrophy (dryness, itching, burning) and to help prevent postmenopausal osteoporosis.
Combipatch delivers estradiol (an estrogen) and norethindrone acetate (a progestin) through the skin into the bloodstream. The estrogen component replaces declining hormone levels during menopause, while the progestin component protects the uterine lining from the potentially harmful effects of estrogen alone.
Combipatch is typically applied twice weekly to the lower abdomen. Common side effects may include skin irritation at the application site, breast tenderness, headache, and mood changes. Women should discuss their complete medical history with their healthcare provider before use, as HRT may increase the risk of certain conditions including blood clots, stroke, and certain cancers.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy