Conivaptan Hydrochloride
Conivaptan Hydrochloride is a vasopressin receptor antagonist used primarily in hospital settings to treat euvolemic and hypervolemic hyponatremia (low sodium levels). It works by blocking vasopressin V2 receptors in the kidney, promoting water excretion while helping restore sodium balance. This medication is administered intravenously and requires close monitoring due to potential side effects.
Conivaptan is an IV medication that treats low sodium by helping the kidneys remove excess water while preserving electrolytes.
Key facts at a glance
- RxNorm
- 1294548
- Generic
- Conivaptan Hydrochloride
- Class
- pin-variant
- Brands
- Vaprisol
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of euvolemic hyponatremia and hypervolemic hyponatremia in hospitalized patients. It may also be used in conditions where excessive vasopressin causes water retention.
Conivaptan blocks vasopressin V2 receptors in the renal collecting ducts, preventing water reabsorption and promoting aquaresis (excretion of free water), which helps normalize serum sodium levels.
Administered intravenously in clinical settings. Requires monitoring of serum sodium, fluid status, and liver function. May cause infusion site reactions, electrolyte abnormalities, or hypotension. Use is typically limited to short-term treatment in hospitalized patients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy