Crenessity
Crenessity (crinecerfont) is a corticotropin-releasing factor receptor 1 (CRF1) antagonist used to treat congenital adrenal hyperplasia (CAH). It works by blocking CRF signaling in the pituitary gland, which reduces the overproduction of adrenal androgens that are elevated in CAH. This medication is used in both adults and pediatric patients with classic and non-classic forms of CAH to help manage androgen excess.
Crenessity is a CRF1 receptor antagonist used to treat congenital adrenal hyperplasia by reducing excess androgen production.
Key facts at a glance
- RxNorm
- 2701392
- Generic
- Crenessity
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Crenessity is indicated for the treatment of classic and non-classic congenital adrenal hyperplasia (CAH) in adults and pediatric patients 4 years and older. It is used to manage androgen excess in patients with CAH due to 21-hydroxylase deficiency.
Crenessity works as a corticotropin-releasing factor receptor 1 (CRF1) antagonist. By blocking CRF receptors in the pituitary gland, it reduces the excessive stimulation of ACTH secretion, which in turn decreases the overproduction of adrenal androgens.
Crenessity should be taken twice daily orally. Patients should be monitored for changes in adrenal hormone levels. Common side effects may include fatigue, headache, and dizziness. It is not a substitute for emergency glucocorticoid stress dosing in adrenal crisis situations.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy