Crizotinib
Crizotinib is a targeted cancer therapy that inhibits specific receptor tyrosine kinases, including ALK, ROS1, c-Met, and RON. It is primarily used to treat ALK-positive and ROS1-positive non-small cell lung cancer, working by blocking signals that drive cancer cell growth and survival.
Crizotinib is a targeted therapy for ALK-positive and ROS1-positive lung cancers that inhibits key tyrosine kinases to halt cancer progression.
Key facts at a glance
- ATC
- L01ED01
- RxNorm
- 1148495
- Generic
- Crizotinib
- Class
- atc-l01
- Brands
- Xalkori
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Treatment of ALK-positive and ROS1-positive non-small cell lung cancer (NSCLC). May also be used in other cancers with these genetic alterations.
Inhibits ALK, ROS1, c-Met (HGFR), and RON receptor tyrosine kinases. Blocks signaling pathways that promote cancer cell proliferation, survival, and spread.
May cause serious side effects including liver toxicity, pneumonitis, QT prolongation, and vision changes. Requires regular monitoring. Avoid grapefruit juice and inform your doctor of all medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy