Cyclobenzaprine Hydrochloride
Cyclobenzaprine Hydrochloride is a centrally-acting muscle relaxant used to relieve painful muscle spasms and stiffness associated with acute musculoskeletal conditions. It is typically prescribed for short-term use (2-3 weeks) alongside rest and physical therapy. The medication works by blocking nerve impulses sent to the brain, helping reduce muscle hyperactivity and discomfort.
A short-term muscle relaxant used to treat acute muscle spasms and associated pain.
Key facts at a glance
- RxNorm
- 52101
- Generic
- Cyclobenzaprine Hydrochloride
- Class
- pin-variant
- Brands
- Tonmya, Fexmid, Amrix
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Cyclobenzaprine is indicated for the symptomatic relief of painful muscle spasms associated with acute musculoskeletal conditions such as strains, sprains, and other traumatic injuries. It is not intended for long-term use.
Cyclobenzaprine acts primarily on the brainstem, reducing tonic somatic motor activity. While its exact mechanism is not fully established, it is structurally related to tricyclic antidepressants and is thought to inhibit polysynaptic reflexes involved in muscle contraction.
Use is generally limited to 2-3 weeks due to limited evidence of effectiveness for longer periods. It may cause drowsiness and should be used with caution when operating machinery or consuming alcohol. Not recommended for patients with hyperthyroidism, heart failure, arrhythmias, or recent MI. Anticholinergic side effects may occur.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy