Cyclophosphamide Monohydrate
Cyclophosphamide Monohydrate is an alkylating agent chemotherapy medication that works by interfering with DNA replication in rapidly dividing cells, leading to cell death. It is used to treat various cancers including lymphomas, leukemias, and certain solid tumors, and may also be used as an immunosuppressant for autoimmune conditions.
A chemotherapy alkylating agent used to treat cancers and autoimmune disorders by disrupting DNA in rapidly dividing cells.
Key facts at a glance
- RxNorm
- 2679071
- Generic
- Cyclophosphamide Monohydrate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Cyclophosphamide is used to treat Hodgkin's lymphoma, non-Hodgkin lymphoma, leukemia, multiple myeloma, neuroblastoma, ovarian cancer, breast cancer, and sarcomas. It is also used off-label for severe autoimmune conditions such as lupus, vasculitis, and autoimmune kidney diseases.
As an alkylating agent, cyclophosphamide is converted in the liver to active metabolites that bind to and cross-link DNA strands, preventing cancer or immune cells from replicating and ultimately causing cell death.
Common side effects include bone marrow suppression, nausea, hair loss, and increased infection risk. Adequate hydration is essential to reduce risk of hemorrhagic cystitis. Regular blood count monitoring is required during treatment. May cause infertility and should not be used during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy