Cyproheptadine Pyrid Phos
Cyproheptadine Pyrid Phos is a first-generation antihistamine with antiserotonergic properties, available as a phosphate salt formulation. It works by blocking histamine H1 receptors and serotonin receptors in the body. This medication is primarily used for allergic conditions, appetite stimulation, and occasionally for migraine prevention in certain patient populations.
An antihistamine used for allergies, appetite stimulation, and sometimes migraines, working through histamine and serotonin receptor blockade.
Key facts at a glance
- RxNorm
- 236525
- Generic
- Cyproheptadine Pyrid Phos
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of seasonal and perennial allergic rhinitis, allergic skin conditions (urticaria, pruritus), and appetite stimulation. May be used off-label for migraine headache prophylaxis in some cases.
Acts as a competitive antagonist at H1 histamine receptors and serotonin (5-HT2) receptors, reducing allergic symptoms and potentially affecting appetite regulation through serotonin modulation.
Causes significant drowsiness; avoid alcohol and operating machinery. Use with caution in elderly patients, those with glaucoma, urinary retention, or cardiovascular conditions. Not recommended during acute asthma attacks. May interact with CNS depressants and MAO inhibitors.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy