Dabrafenib
Dabrafenib is a targeted therapy medication that inhibits mutated forms of BRAF kinases, which drive cancer cell growth. It is primarily used to treat melanoma, non-small cell lung cancer, and anaplastic thyroid cancer in patients with specific BRAF mutations.
A BRAF kinase inhibitor used to treat certain cancers with BRAF mutations.
Key facts at a glance
- ATC
- L01EC02
- RxNorm
- 1424911
- Generic
- Dabrafenib
- Class
- atc-l01
- Brands
- Tafinlar
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of melanoma with BRAF V600E or V600K mutations, non-small cell lung cancer with BRAF V600E mutation, and anaplastic thyroid cancer with BRAF V600E mutation. May be used alone or in combination with other targeted agents.
Inhibits mutated BRAF kinases (V600E, V600K, V600D) that are overactive in certain cancers, blocking signals that promote cancer cell growth and survival. Often combined with MEK inhibitors to reduce treatment resistance.
Requires confirmed BRAF mutation testing before use. Common side effects include fever, fatigue, headache, and skin reactions. Can cause skin cancers in some patients. Monitor for liver problems and bleeding. May be combined with trametinib for improved outcomes.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy