Dacomitinib
Dacomitinib is an irreversible tyrosine kinase inhibitor used to treat adults with advanced non-small cell lung cancer (NSCLC) that has specific EGFR mutations (exon 19 deletion or exon 21 L858R substitution). It works by blocking the activity of EGFR family proteins (HER1/EGFR, HER2, and HER4), which are involved in cancer cell growth and survival.
Dacomitinib is a targeted therapy for EGFR-mutated lung cancer that irreversibly blocks EGFR family kinases to inhibit tumor growth.
Key facts at a glance
- ATC
- L01EB07
- RxNorm
- 2058849
- Generic
- Dacomitinib
- Class
- atc-l01
- Brands
- Vizimpro
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Treatment of adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR activating mutations (exon 19 deletion or exon 21 L858R substitution).
Irreversibly inhibits the kinase activity of the human EGFR family (EGFR/HER1, HER2, HER4) and certain EGFR activating mutations, preventing cancer cell signaling and growth. In vitro, it also inhibits DDR1.
Common side effects include diarrhea, skin rash, nail disorders, and stomatitis. Requires confirmation of EGFR mutation status before treatment initiation. Patients should be monitored for interstitial lung disease and QT prolongation.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy