Dantrolene Sodium
Dantrolene Sodium is a direct-acting skeletal muscle relaxant used primarily for managing malignant hyperthermia, a potentially fatal reaction to certain anesthetic agents. It is also prescribed for chronic spasticity conditions such as multiple sclerosis, spinal cord injury, and stroke. The medication acts directly on skeletal muscle to reduce spasticity and prevent the hypermetabolic crisis associated with malignant hyperthermia.
Dantrolene Sodium is a muscle relaxant used to treat malignant hyperthermia and chronic spasticity conditions.
Key facts at a glance
- RxNorm
- 3106
- Generic
- Dantrolene Sodium
- Class
- pin-variant
- Brands
- Revonto, Ryanodex, Dantrium
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of malignant hyperthermia crisis; management of chronic spasticity due to upper motor neuron lesions including multiple sclerosis, spinal cord injury, stroke, and cerebral palsy when oral therapy is needed.
Acts directly on skeletal muscle by inhibiting calcium release from the sarcoplasmic reticulum through ryanodine receptors, thereby reducing muscle contraction strength and relieving spasticity.
May cause hepatotoxicity; requires liver function monitoring. Can cause significant muscle weakness. For IV use in malignant hyperthermia emergencies, reconstitute carefully and administer by direct IV push. Oral form requires regular monitoring of liver function tests. Contraindicated in patients with active hepatic disease.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy