Pyrimethamine
Daraprim (pyrimethamine) is an antiparasitic medication primarily used to treat toxoplasmosis and certain types of malaria. It works by inhibiting parasite growth and is often used in combination with other medications. This medication is particularly important for immunocompromised patients, such as those with HIV/AIDS, who are at risk for serious toxoplasmosis infections.
Daraprim is an antiparasitic medication used to treat toxoplasmosis and malaria, particularly important for immunocompromised patients.
Key facts at a glance
- RxNorm
- 151583
- Generic
- Daraprim
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of toxoplasmosis, including in immunocompromised patients such as those with HIV/AIDS; treatment of malaria (often as part of combination therapy); may be used for other parasitic infections as determined by a healthcare provider.
Pyrimethamine acts as a folate antagonist by inhibiting dihydrofolate reductase in parasites. This interferes with DNA synthesis in the parasites, preventing their growth and reproduction. It is often used with other medications to enhance effectiveness.
Should only be used under medical supervision; often combined with other medications (such as sulfadiazine for toxoplasmosis); folinic acid is commonly given alongside to reduce bone marrow side effects; not typically used as a first-line malaria treatment in many regions due to resistance concerns.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy