Daridorexant
Daridorexant is a prescription sleep medication that works by blocking orexin receptors in the brain. It is used to treat insomnia in adults, helping to reduce the time it takes to fall asleep and improve sleep maintenance. By inhibiting the orexin neuropeptide system, which promotes wakefulness, daridorexant facilitates the transition to sleep.
Daridorexant is an orexin receptor antagonist used to treat insomnia by promoting sleep onset and maintenance.
Key facts at a glance
- ATC
- N05CJ03
- RxNorm
- 2591497
- Generic
- Daridorexant
- Class
- atc-n05
- Brands
- Quviviq
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Daridorexant is FDA-approved for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance in adults.
Daridorexant acts as a dual orexin receptor antagonist (DORA). It blocks the binding of wake-promoting neuropeptides orexin A and orexin B to their receptors, thereby reducing the drive to stay awake and promoting sleep.
Daridorexant is taken orally, typically at bedtime. It should be used with caution in patients with hepatic impairment. Common side effects may include headache, somnolence, and fatigue. Patients should avoid alcohol and should not drive until they know how the medication affects them. Use during pregnancy should be discussed with a healthcare provider.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy