Daridorexant Hydrochloride
Daridorexant Hydrochloride is an orexin receptor antagonist used to treat insomnia in adults. It works by blocking the action of orexin, a neurotransmitter that promotes wakefulness, thereby facilitating sleep onset and maintenance. This medication is typically prescribed for individuals with difficulty falling asleep or staying asleep.
An orexin receptor antagonist used to treat insomnia by reducing wakefulness signals in the brain.
Key facts at a glance
- RxNorm
- 2591496
- Generic
- Daridorexant Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance in adults.
As an orexin receptor antagonist, it blocks the binding of orexin neuropeptides (orexin A and orexin B) to orexin receptors OX1R and OX2R, which normally promote wakefulness and arousal.
Take within 30 minutes before bedtime with at least 7 hours remaining before waking. May cause next-day drowsiness, CNS depression, and sleep paralysis. Avoid use with strong CYP3A4 inhibitors. Not recommended during pregnancy or breastfeeding. Controlled substance scheduling varies by country.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy