Darolutamide
Darolutamide is an androgen receptor inhibitor used to treat prostate cancer. It works by blocking the androgen receptor at multiple stages - preventing androgens from binding, blocking their transport to the cell nucleus, and inhibiting gene transcription that drives cancer growth. This oral medication is typically prescribed for men with non-metastatic castration-resistant prostate cancer.
Darolutamide is an oral androgen receptor inhibitor used to treat prostate cancer by blocking male hormones from promoting cancer growth.
Key facts at a glance
- ATC
- L02BB06
- RxNorm
- 2180325
- Generic
- Darolutamide
- Class
- atc-l02
- Brands
- Nubeqa
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC) in combination with androgen deprivation therapy.
Darolutamide competitively inhibits androgen binding to the androgen receptor, prevents AR nuclear translocation, and blocks AR-mediated transcription. Its active metabolite ketodarolutamide has similar anti-tumor activity.
Contraindicated in pregnancy due to teratogenicity. May cause fatigue, neutropenia, and hepatotoxicity. Patients should use effective contraception during and after treatment. Drug interactions may occur with strong CYP3A4 inducers and inhibitors.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy