Darunavir
Darunavir is an antiretroviral medication classified as a protease inhibitor, used in combination with other HIV medications to treat HIV-1 infection in adults and children. It works by blocking the HIV protease enzyme, which is essential for the virus to replicate and assemble new infectious particles.
Darunavir is an HIV-1 protease inhibitor used with other antiretrovirals to treat HIV infection.
Key facts at a glance
- ATC
- J05AE10
- RxNorm
- 460132
- Generic
- Darunavir
- Class
- atc-j05
- Brands
- Prezcobix, Symtuza, Prezista
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in adults and children (typically used in treatment-experienced patients or those with known resistance to other protease inhibitors). Used as part of combination antiretroviral therapy.
Darunavir is a non-peptidic protease inhibitor that binds reversibly to the active site of the HIV-1 protease enzyme, preventing the cleavage of viral polyprotein precursors essential for the formation of mature, infectious viral particles.
Must be taken with a meal or snack for optimal absorption. Always used with a pharmacokinetic booster (ritonavir or cobicistat). Resistance may develop if used as monotherapy or with suboptimal combinations. Patients should be monitored for liver function, rash, and drug interactions. Not a cure for HIV.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy