Darunavir Hydrate
Darunavir Hydrate is an antiretroviral medication classified as a protease inhibitor, used in combination with other HIV medications for the treatment of HIV-1 infection. It is typically prescribed for treatment-experienced patients, including those who have developed resistance to other antiretroviral drugs.
Darunavir is an HIV protease inhibitor used in combination therapy for the treatment of HIV infection, particularly in patients with prior treatment experience.
Key facts at a glance
- RxNorm
- 2637854
- Generic
- Darunavir Hydrate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in combination with other antiretroviral agents. Commonly used in patients with prior antiretroviral treatment experience, including those with documented resistance to other protease inhibitors.
Darunavir inhibits the HIV protease enzyme, which is essential for cleaving viral polyproteins into functional proteins required for viral maturation and replication. It is typically co-administered with low-dose ritonavir or cobicistat as a pharmacokinetic booster to increase drug exposure.
May cause hepatotoxicity, severe skin reactions, and sulfonamide allergy cross-reactivity. Should be taken with food. Always used as part of combination antiretroviral therapy, not as monotherapy. Requires appropriate patient counseling on adherence and potential drug interactions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy