Dasiglucagon
Dasiglucagon is a glucagon receptor agonist designed to treat severe hypoglycemia by stimulating the liver to release stored glucose into the bloodstream. It activates hepatic glucagon receptors, triggering glycogen breakdown and increasing blood glucose levels. This medication is primarily used for emergency treatment of dangerously low blood sugar in diabetic patients.
Dasiglucagon is an injectable emergency treatment for severe hypoglycemia that rapidly raises blood sugar by stimulating the liver to release stored glucose.
Key facts at a glance
- ATC
- H04AA02
- RxNorm
- 2535233
- Generic
- Dasiglucagon
- Class
- atc-h04
- Brands
- Zegalogue
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 0.6 mg
- Maximum
- consult physician
- Frequency
- single dose as needed for severe hypoglycemia
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.6 mg
- Maximum
- consult physician
- Frequency
- single dose as needed for severe hypoglycemia
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.6 mg
- Maximum
- consult physician
- Frequency
- single dose as needed for severe hypoglycemia
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
use only if benefits outweigh potential risks to fetus
regular fetal monitoring recommended
Use with caution and monitor for adverse effects.
pregnancy
second trimesteruse lowest effective dose
use only if benefits outweigh potential risks
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse lowest effective dose
use only if benefits outweigh potential risks
regular fetal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment needed
discontinue breastfeeding or avoid use if severe hypoglycemia occurs
monitor infant for adverse effects
geriatric
elderlyno specific adjustment
use with caution due to potential comorbidities and concurrent medications
monitor blood glucose and vital signs closely
Use with caution and monitor for adverse effects.
pediatric_age
children 6 to 17weight-based dosing
approved for pediatric patients 6 years and older for severe hypoglycemia
monitor for recurrence of hypoglycemia
renal_impairment
mild to moderateno specific adjustment
use with caution, monitor renal function
monitor renal function and blood glucose
Use with caution and monitor for adverse effects.
hepatic_impairment
mild to moderateno specific adjustment
use with caution, monitor hepatic function
monitor liver function and blood glucose
Use with caution and monitor for adverse effects.
Statistics and clinical data
FDA approval year
First FDA approval date for Zegalogue
Drug class
Pharmacological classification
Common uses
Primary therapeutic indication
Mechanism of action
Pharmacodynamic mechanism
Emergency treatment of severe hypoglycemia in patients with diabetes who cannot take oral glucose (e.g., during unconsciousness or when unable to swallow)
Acts as a glucagon receptor agonist in the liver, stimulating glycogen breakdown and promoting the release of stored glucose into the bloodstream to raise blood sugar levels rapidly
Effectiveness depends on adequate hepatic glycogen stores; administered by subcutaneous injection; should be part of a comprehensive hypoglycemia emergency plan; patients and caregivers should receive proper training on administration
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy