Datopotamab Deruxtecan-Dlnk
Datopotamab deruxtecan-dlnk is a novel antibody-drug conjugate (ADC) targeting TROP2, a protein highly expressed in various solid tumors. It delivers a potent cytotoxic agent (deruxtecan) directly to cancer cells, minimizing damage to healthy tissues. This medication is being investigated for the treatment of advanced solid malignancies, particularly non-small cell lung cancer and breast cancer.
An investigational TROP2-targeting antibody-drug conjugate for solid tumors that delivers chemotherapy directly to cancer cells.
Key facts at a glance
- RxNorm
- 2703034
- Generic
- Datopotamab Deruxtecan-Dlnk
- Class
- pin-variant
- Brands
- Datroway
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Under investigation for multiple solid tumor types, with primary focus on advanced or metastatic non-small cell lung cancer (NSCLC) and hormone receptor-positive/HER2-negative breast cancer. Clinical trials are ongoing for other TROP2-expressing malignancies.
As a TROP2-directed ADC, it binds to TROP2 on cancer cell surfaces, undergoes internalization, and releases the deruxtecan payload inside the cell. Deruxtecan is a topoisomerase I inhibitor that causes DNA damage and induces cell death.
This is an investigational agent not yet FDA-approved. Common adverse effects include nausea, fatigue, and alopecia. Monitor for interstitial lung disease and severe neutropenia. Requires careful patient selection based on TROP2 expression testing.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy