Debrisoquine Sulfate
Debrisoquine Sulfate is an antihypertensive agent that works by blocking alpha-adrenergic receptors, leading to vasodilation and reduced blood pressure. It was historically used in the management of moderate to severe hypertension, though its use has declined in favor of newer agents with more favorable side effect profiles. The medication requires careful dose titration and blood pressure monitoring during treatment initiation.
Debrisoquine Sulfate is an older antihypertensive medication that lowers blood pressure by blocking alpha-adrenergic receptors.
Key facts at a glance
- RxNorm
- 203120
- Generic
- Debrisoquine Sulfate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for the treatment of hypertension (high blood pressure). May have been used in cases where other antihypertensive agents were not effective or tolerated. Not commonly prescribed in modern clinical practice.
Acts as a competitive antagonist at alpha-adrenergic receptors, preventing catecholamines (like norepinephrine) from causing vasoconstriction. This results in relaxation of vascular smooth muscle, vasodilation, and subsequently reduced blood pressure.
May cause orthostatic hypotension, dizziness, and reflex tachycardia. Requires careful titration to avoid excessive blood pressure reduction. Contraindicated in patients with pheochromocytoma. Drug interactions may occur with other antihypertensives and sympathomimetics. Use during pregnancy should be carefully considered against potential risks.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy