Defactinib Hydrochloride
Defactinib Hydrochloride is an investigational small molecule inhibitor of focal adhesion kinase (FAK), a protein involved in cell signaling pathways that regulate tumor growth, survival, and metastasis. It has been studied primarily in clinical trials for various solid tumors, including pancreatic cancer and malignant pleural mesothelioma.
Defactinib Hydrochloride is an investigational FAK inhibitor being studied for the treatment of solid tumors.
Key facts at a glance
- RxNorm
- 2714501
- Generic
- Defactinib Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Investigated for treatment of solid tumors, particularly pancreatic cancer and malignant pleural mesothelioma. Clinical trials have explored its use both as monotherapy and in combination with other anticancer agents.
Functions as a selective inhibitor of focal adhesion kinase (FAK), blocking downstream signaling pathways involved in tumor cell proliferation, survival, and invasive capacity.
Defactinib is an investigational agent not currently approved by regulatory authorities. Common adverse effects in clinical trials included fatigue, nausea, and diarrhea. Patients should only receive this medication through enrollment in clinical trials under physician supervision.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy