Deferasirox
Deferasirox is an oral iron chelating agent used to treat chronic iron overload in patients with transfusion-dependent anemias such as beta-thalassemia, sickle cell disease, and myelodysplastic syndromes. It works by selectively binding to excess iron in the body and facilitating its excretion, thereby preventing organ damage from iron accumulation.
An oral iron chelator that removes excess iron from the body in patients with iron overload conditions.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- V03AC03
- RxNorm
- 614373
- Generic
- Deferasirox
- Class
- atc-v03a
- Brands
- Jadenu, Exjade
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic iron overload due to regular blood transfusions in adults and children with transfusion-dependent anemias, including beta-thalassemia, sickle cell disease, and other rare anemias. Also used in non-transfusion-dependent thalassemia syndromes with iron overload.
An orally active tridentate chelator with high selectivity for ferric iron (Fe3+). It binds to iron in a 2:1 ratio, creating a stable complex that can be eliminated from the body primarily through feces and urine. The drug has very low affinity for other essential metals like zinc and copper.
Requires regular monitoring of serum ferritin, renal function, and hepatic function. Common side effects may include gastrointestinal symptoms, skin reactions, and headache. Rare but serious adverse effects can include kidney impairment, liver dysfunction, and blood disorders. Patients should be advised about potential interactions with other medications and the importance of adherence to therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy