Defibrotide, Bovine Lung
Defibrotide is a polynucleotides medication derived from bovine lung tissue used to treat severe hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, in patients undergoing hematopoietic stem cell transplantation. It exhibits antithrombotic and fibrinolytic properties and helps restore endothelial function in damaged hepatic blood vessels.
A bovine lung-derived medication used to treat severe veno-occlusive disease following stem cell transplantation.
Key facts at a glance
- RxNorm
- 1788946
- Generic
- Defibrotide, Bovine Lung
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of severe hepatic veno-occlusive disease (VOD) in patients undergoing hematopoietic stem cell transplantation, particularly when associated with renal or pulmonary dysfunction.
Exerts antithrombotic and fibrinolytic effects by modulating endothelial cell function and restoring the balance between coagulation and fibrinolysis in the hepatic sinusoids.
Administered via intravenous infusion; contraindicated in patients with known hypersensitivity to defibrotide or any component; may increase bleeding risk and should not be used with anticoagulants or fibrinolytic agents.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy