Delafloxacin
Delafloxacin (BAXDELA) is a fluoroquinolone antibiotic used to treat acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). It works by inhibiting bacterial DNA replication enzymes, effectively killing susceptible bacteria. This medication is typically prescribed for adults with serious bacterial infections when other antibiotics may not be suitable.
Delafloxacin is a fluoroquinolone antibiotic used to treat serious skin infections and pneumonia caused by susceptible bacteria.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- J01MA23
- RxNorm
- 1927663
- Generic
- Delafloxacin
- Class
- atc-j01
- Brands
- Baxdela
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- injection, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP) in adults caused by susceptible gram-positive and gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).
Delafloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, and repair, leading to bacterial cell death.
May cause tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects. Contraindicated in patients with known fluoroquinolone hypersensitivity. Use with caution in patients with QT prolongation, renal impairment, or myasthenia gravis. Associated with increased risk of C. difficile infection.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy