Delavirdine
Delavirdine is an antiretroviral medication classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination therapy for the treatment of HIV-1 infection. It works by inhibiting the reverse transcriptase enzyme, preventing viral replication of HIV. While once commonly used, it has been largely replaced by newer antiretroviral agents with improved efficacy and tolerability profiles.
Delavirdine is an older HIV medication (NNRTI) used in combination therapy, now seldom prescribed due to newer alternatives.
Key facts at a glance
- ATC
- J05AG02
- RxNorm
- 83816
- Generic
- Delavirdine
- Class
- atc-j05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in combination with other antiretroviral agents. Not recommended as initial therapy due to superior alternatives available.
Non-competitive inhibition of HIV-1 reverse transcriptase enzyme, blocking viral RNA-dependent DNA synthesis and preventing viral replication.
Requires combination therapy—never used alone. Significant drug interactions with many medications including other antiretrovirals, acid-reducing agents, and certain statins. Requires adherence to dosing schedule. Rarely used in modern practice due to availability of better-tolerated and more effective NNRTIs like efavirenz, nevirapine, and rilpivirine.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy