Demeclocycline
Demeclocycline is a tetracycline-class antibiotic used to treat various bacterial infections. It is particularly notable for its use in treating Syndrome of Inappropriate Antidiuretic Hormone (SIADH), where it helps reduce excessive water retention by inducing nephrogenic diabetes insipidus. This medication is typically reserved for situations when first-line antibiotics are not suitable.
Demeclocycline is a tetracycline antibiotic primarily used for bacterial infections and SIADH, a condition causing abnormal water retention.
Key facts at a glance
- ATC
- D06AA01
- RxNorm
- 3154
- Generic
- Demeclocycline
- Class
- atc-d06
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of susceptible bacterial infections including respiratory tract infections, urinary tract infections, and skin infections; also specifically indicated for Syndrome of Inappropriate Antidiuretic Hormone (SIADH) to promote water excretion.
As a tetracycline antibiotic, it inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. In SIADH, it acts on the collecting ducts of the kidneys to reduce their responsiveness to antidiuretic hormone (ADH), thereby promoting water excretion.
Photosensitivity reactions are common; avoid prolonged sun exposure. May cause tooth discoloration and affect bone development in fetuses and children. Contraindicated during pregnancy and in children under 8 years old. Requires adequate fluid intake to prevent esophageal irritation and kidney damage. Effectiveness of oral contraceptives may be reduced.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy