Depemokimab
Depemokimab is a humanized monoclonal antibody that targets interleukin-5 (IL-5), a key cytokine involved in eosinophil activation and survival. It is designed to treat conditions driven by eosinophilic inflammation, such as severe eosinophilic asthma and potentially other eosinophil-mediated diseases.
An IL-5 inhibitor monoclonal antibody for treating eosinophil-driven inflammatory conditions.
Key facts at a glance
- ATC
- R03DX12
- RxNorm
- 2729265
- Generic
- Depemokimab
- Class
- atc-r03
- Brands
- Exdensur
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
10 groupspregnancy
first trimestercontinue if needed for asthma control
use only if benefits outweigh potential risks to fetus
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimestercontinue if needed for asthma control
maintain therapy if needed to prevent asthma exacerbations
routine fetal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimestercontinue if needed
do not discontinue therapy as uncontrolled asthma increases perinatal risks
fetal growth and wellbeing monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment needed
compatible with breastfeeding
none required
geriatric
elderly 65 plusno adjustment needed
use standard dosing, monitor for comorbidities
regular assessment of organ function
pediatric_age
adolescents 12 17use adult dosing
approved for severe eosinophilic asthma in patients 12 years and older
growth and development monitoring
renal_impairment
mild moderateno adjustment needed
biologics not renally cleared, standard dosing applies
routine renal function monitoring
renal_impairment
severeno adjustment needed
monoclonal antibodies degraded systemically, not renally eliminated
monitor renal function periodically
hepatic_impairment
mild moderateno adjustment needed
standard dosing recommended
routine liver function monitoring
hepatic_impairment
severeuse with caution
limited data in severe hepatic impairment, monitor closely
regular hepatic function assessment
Use with caution and monitor for adverse effects.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Mechanism of action
Pharmacological mechanism
Common uses
Common therapeutic uses
Treats severe eosinophilic asthma and other conditions characterized by elevated eosinophil counts driven by IL-5, such as eosinophilic granulomatosis with polyangiitis (EGPA).
As an IL-5 antagonist, it binds to IL-5 with high affinity (Kd=10.5 pM), blocking its interaction with the IL-5 receptor alpha chain and inhibiting eosinophil activation, survival, and inflammatory responses.
Administered as an injectable biologic; requires proper diagnosis of eosinophilic phenotype; monitor for hypersensitivity reactions and parasitic infections.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy