Penicillamine
Depen is a brand-name chelating agent primarily used to treat Wilson's disease by removing excess copper from the body, as well as cystinuria to prevent kidney stone formation. It may also be prescribed for certain cases of rheumatoid arthritis when other treatments are not suitable.
Depen is a chelating medication used to treat Wilson's disease, cystinuria, and occasionally rheumatoid arthritis by removing excess metals from the body.
Key facts at a glance
- RxNorm
- 216462
- Generic
- Depen
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Depen is primarily indicated for Wilson's disease (to reduce copper levels), cystinuria (to prevent formation of cystine kidney stones), and in some cases for rheumatoid arthritis when conventional therapies are inadequate or not tolerated.
Depen acts as a chelating agent that binds to certain metals in the body, forming complexes that are then excreted through the kidneys via urine.
Depen should only be used under close medical supervision with regular monitoring of blood counts and kidney function. Common side effects may include gastrointestinal upset, loss of taste, and skin reactions. It should not be used during pregnancy except in life-threatening situations. Patients should inform their doctor of all medications being taken to avoid potential interactions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy