Fluocinolone acetonide
Derma-Smoothe FS is a topical corticosteroid medication containing fluocinolone acetonide used to treat inflammatory and itchy skin conditions. The oil-based formulation helps moisturize dry, flaky skin while delivering the active ingredient to reduce redness, swelling, and itching. It is commonly prescribed for conditions such as eczema, psoriasis, and other dermatological inflammatory disorders.
Derma-Smoothe FS is a topical corticosteroid cream used to treat inflammatory skin conditions like eczema and psoriasis by reducing itching, redness, and swelling.
Key facts at a glance
- RxNorm
- 352578
- Generic
- Derma-Smoothe Fs
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats inflammatory and pruritic (itchy) skin conditions including atopic dermatitis (eczema), psoriasis, seborrheic dermatitis, and other corticosteroid-responsive dermatoses. Particularly useful for dry, scaly skin conditions.
Contains fluocinolone acetonide, a medium-potency topical corticosteroid that works by suppressing the immune response and reducing inflammation. It decreases the production of inflammatory substances and inhibits the migration of inflammatory cells to the affected area, thereby relieving swelling, redness, and itching.
For external use only; avoid contact with eyes, mouth, and open wounds. Should not be used on large body areas, broken skin, or for prolonged periods without medical supervision due to risk of systemic absorption. Not recommended for use in children under certain ages without physician guidance. Common side effects may include skin irritation, dryness, or temporary worsening of symptoms. Avoid using occlusive dressings unless specifically directed by a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy