Desirudin
Desirudin is a direct thrombin inhibitor used as an anticoagulant to prevent blood clots. It is primarily prescribed for the prevention of venous thromboembolism in patients undergoing major orthopedic surgery, such as hip or knee replacement procedures. As a recombinant form of hirudin derived from leech saliva, it provides potent antithrombotic effects by directly inhibiting thrombin in the coagulation cascade.
Desirudin is an anticoagulant injection used to prevent blood clots after orthopedic surgery.
Key facts at a glance
- ATC
- B01AE01
- RxNorm
- 114934
- Generic
- Desirudin
- Class
- atc-b01
- Brands
- Iprivask
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of venous thromboembolism (VTE) in patients undergoing major orthopedic surgery, particularly hip or knee replacement surgery. It may also be considered for other surgical settings where VTE prevention is needed.
Desirudin is a direct thrombin inhibitor that binds reversibly to both free thrombin and thrombin bound to fibrin, preventing the conversion of fibrinogen to fibrin and inhibiting thrombus formation in the coagulation cascade.
Administered by subcutaneous injection. Contraindicated in patients with severe renal impairment, active bleeding, or known hypersensitivity. Risk of bleeding complications requires careful monitoring. Not typically used with other anticoagulants due to increased hemorrhage risk.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy