Desvenlafaxine Succinate
Desvenlafaxine Succinate is an antidepressant medication classified as a serotonin-norepinephrine reuptake inhibitor (SNRI). It is primarily prescribed to treat major depressive disorder (MDD) in adults by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.
Desvenlafaxine Succinate is an SNRI antidepressant used to treat major depressive disorder by increasing serotonin and norepinephrine levels in the brain.
Key facts at a glance
- RxNorm
- 683693
- Generic
- Desvenlafaxine Succinate
- Class
- pin-variant
- Brands
- Pristiq
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Desvenlafaxine Succinate is FDA-approved for the treatment of major depressive disorder (MDD) in adults. It may also be used off-label for conditions such as generalized anxiety disorder, vasomotor symptoms associated with menopause, and certain pain conditions.
As an SNRI, Desvenlafaxine works by inhibiting the reuptake of both serotonin and norepinephrine in the brain, increasing the availability of these neurotransmitters. It is the active metabolite of venlafaxine and has a dual mechanism that distinguishes it from selective serotonin reuptake inhibitors (SSRIs).
Desvenlafaxine should not be discontinued abruptly, as this may cause withdrawal symptoms. Common side effects include nausea, dry mouth, and dizziness. Patients should be monitored for suicidal thoughts, especially when starting treatment. It may interact with other serotonergic medications and is contraindicated with MAO inhibitors. Not recommended for use during pregnancy unless clearly needed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy