Deucravacitinib
Deucravacitinib is a prescription medication used to treat adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy. It works by selectively inhibiting tyrosine kinase 2 (TYK2), an enzyme involved in the inflammatory signaling pathways that drive autoimmune conditions. By targeting TYK2 specifically, it helps reduce the excessive immune response that causes psoriasis symptoms.
Deucravacitinib is an oral TYK2 inhibitor used to treat moderate to severe plaque psoriasis by reducing inflammation through targeted suppression of immune signaling pathways.
Key facts at a glance
- ATC
- L04AF07
- RxNorm
- 2612087
- Generic
- Deucravacitinib
- Class
- atc-l04
- Brands
- Sotyktu
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. It is typically used when other treatments have not been effective or are not suitable.
Deucravacitinib selectively inhibits TYK2, a member of the Janus kinase (JAK) family. It binds to the regulatory domain of TYK2, stabilizing an inhibitory interaction between the regulatory and catalytic domains, thereby blocking downstream inflammatory signaling cascades involved in autoimmune pathogenesis.
Deucravacitinib is an immunosuppressant and may increase the risk of infections. Patients should be screened for tuberculosis before starting treatment. Common side effects may include upper respiratory infections, headache, and rash. Regular monitoring may be required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy