Dexfenfluramine Hydrochloride
Dexfenfluramine Hydrochloride is a serotonin-releasing agent that was previously prescribed as an appetite suppressant for the treatment of obesity. It functioned by increasing serotonin levels in the brain to promote satiety. The medication was withdrawn from markets worldwide in the late 1990s due to associated cardiac risks.
An appetite suppressant that was withdrawn from the market due to serious cardiovascular safety concerns.
Key facts at a glance
- RxNorm
- 155142
- Generic
- Dexfenfluramine Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dexfenfluramine was indicated for short-term weight management in clinically obese patients. It was typically prescribed as part of a comprehensive weight loss program that included dietary changes and exercise. The medication was commonly used in combination with phentermine (known as 'fen-phen'), though this combination was later found to carry significant health risks.
Dexfenfluramine acts as a serotonin agonist and releaser. It increases serotonin levels in the brain by promoting release and inhibiting reuptake of the neurotransmitter, which leads to enhanced satiety signals and reduced appetite. This appetite suppression helps patients consume fewer calories, supporting weight loss efforts.
This medication was withdrawn from the global market in 1997 due to associations with serious adverse cardiovascular events, including heart valve disease and primary pulmonary hypertension. It is no longer available for prescription. Patients who took this medication should have been advised to consult their healthcare providers for cardiac evaluation. This drug should not be confused with other fenfluramine derivatives still in use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy