Dexrazoxane
Dexrazoxane is a cardioprotective agent used to reduce the risk of heart damage caused by certain chemotherapy drugs called anthracyclines. It works as an iron chelator that penetrates cell membranes and helps prevent the formation of harmful free radicals that can damage heart tissue during cancer treatment.
A cardioprotective agent that helps prevent heart damage in patients receiving anthracycline chemotherapy.
Key facts at a glance
- ATC
- V03AF02
- RxNorm
- 42736
- Generic
- Dexrazoxane
- Class
- atc-v03
- Brands
- Totect
- Availability
- rx
- Pregnancy
- D
- Lactation
- unsafe
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Reduces the risk of congestive heart failure associated with cumulative doxorubicin therapy in patients with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m² and require continued doxorubicin therapy.
Dexrazoxane is a cyclic derivative of EDTA that penetrates cell membranes and is converted intracellularly to an active metabolite that acts as an iron chelator, preventing iron-based free radical formation that causes anthracycline-induced cardiotoxicity.
Should only be used with specific anthracycline regimens for metastatic breast cancer. May increase risk of myelosuppression and is not recommended for use with non-anthracycline chemotherapy. Must be administered as an IV infusion within 30 minutes before anthracycline infusion.
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy