Dibenzepin Hydrochloride
Dibenzepin Hydrochloride is a tricyclic antidepressant (TCA) that was primarily used in some European countries for the treatment of depressive disorders. As a pin-variant TCA, it works by inhibiting the reuptake of neurotransmitters norepinephrine and serotonin in the brain, helping to improve mood and reduce symptoms of depression. This medication has largely fallen out of common use in favor of newer antidepressants with more favorable side effect profiles.
An older tricyclic antidepressant used for depression that increases certain neurotransmitters in the brain, now largely replaced by safer alternatives.
Key facts at a glance
- RxNorm
- 236807
- Generic
- Dibenzepin Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for major depressive disorder and related conditions. Has also been used off-label for anxiety disorders and certain chronic pain conditions, though these uses are less well-documented.
Functions as a norepinephrine and serotonin reuptake inhibitor. By blocking the reuptake of these neurotransmitters at nerve synapses, it increases their availability, helping to regulate mood and emotional state.
Like other tricyclic antidepressants, dibenzepin carries risks of anticholinergic side effects (dry mouth, constipation, urinary retention), sedation, weight gain, and potential cardiac effects. It should not be combined with MAO inhibitors. Due to its side effect profile and the availability of safer antidepressants, it is rarely used today in modern clinical practice.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy