Dichloroacetic Acid
Dichloroacetic acid (DCA) is an investigational compound that has been studied primarily for its potential anti-cancer properties and topical applications. It works by affecting cellular metabolism, particularly targeting enzymes involved in energy production in cells.
Dichloroacetic acid is an investigational agent studied for cancer treatment and topical applications, targeting cellular metabolic pathways.
Key facts at a glance
- RxNorm
- 155021
- Generic
- Dichloroacetic Acid
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
DCA has been investigated for use in certain cancers (particularly brain tumors and metabolic cancers) and has been used topically for warts and keratoses. It has also been studied for lactic acidosis. Importantly, DCA is not FDA-approved for any medical indication and remains an investigational compound.
DCA inhibits pyruvate dehydrogenase kinase (PDK), an enzyme that normally suppresses the pyruvate dehydrogenase complex. This inhibition promotes oxidative metabolism in mitochondria, which may induce apoptosis in cancer cells and normalize lactate metabolism in certain conditions.
DCA is not an approved medication in most countries and should only be used under medical supervision in clinical trials. Side effects may include neurotoxicity (peripheral neuropathy), liver effects, and sedation. Self-medication with DCA is strongly discouraged due to potential serious adverse effects and lack of standardized formulations.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy