Diclegis
Diclegis is a delayed-release combination medication containing doxylamine (an antihistamine) and pyridoxine (vitamin B6) specifically approved for the treatment of nausea and vomiting during pregnancy. It is typically prescribed when dietary and lifestyle modifications have not provided adequate relief from morning sickness symptoms. The medication is the only FDA-approved prescription treatment specifically indicated for pregnancy-related nausea.
Diclegis is a prescription medication combining an antihistamine with vitamin B6, used to treat nausea and vomiting in pregnant women.
Key facts at a glance
- RxNorm
- 1375949
- Generic
- Diclegis
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
FDA-approved for the treatment of nausea and vomiting of pregnancy (NVP), commonly known as morning sickness, when conservative measures have not been effective.
Doxylamine is an antihistamine that blocks H1 receptors and has anticholinergic properties, which are believed to reduce nausea signals. Pyridoxine (vitamin B6) is thought to support normal pregnancy-related nausea control through its role in neurotransmitter synthesis. The delayed-release formulation allows the medication to work throughout the day and night.
Should only be used during pregnancy when benefits outweigh risks. Common side effects include drowsiness, dry mouth, and headache. Patients should avoid driving or operating machinery until they know how the medication affects them. Should be taken on an empty stomach with water. Always consult a healthcare provider before starting any medication during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy