Dicloxacillin
Dicloxacillin is a penicillin-type antibiotic that belongs to the isoxazolyl penicillin subclass. It is used to treat bacterial infections caused by staphylococcus bacteria, particularly strains that produce penicillinase enzymes. This medication is effective against skin infections, soft tissue infections, and other conditions caused by penicillin-resistant staphylococci.
Dicloxacillin is a penicillinase-resistant antibiotic used to treat staphylococcal infections that would otherwise be resistant to standard penicillin antibiotics.
Key facts at a glance
- ATC
- J01CF01
- RxNorm
- 3356
- Generic
- Dicloxacillin
- Class
- atc-j01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of skin and soft tissue infections (including abscesses, cellulitis, wound infections), bone and joint infections, and pneumonia caused by staphylococcus bacteria, particularly penicillinase-producing strains such as Staphylococcus aureus (often referred to as staph infections).
Dicloxacillin works by inhibiting the synthesis of bacterial cell wall peptidoglycan, a critical structural component that maintains bacterial integrity. Its isoxazolyl ring structure provides resistance to beta-lactamase (penicillinase) enzymes produced by certain bacteria, allowing it to remain effective against penicillin-resistant staphylococci.
Patients with penicillin allergies should avoid this medication due to cross-reactivity. It should be taken on an empty stomach (1 hour before or 2 hours after meals) for optimal absorption. Common side effects include gastrointestinal symptoms like nausea and diarrhea. Complete the full prescribed course even if symptoms improve to prevent antibiotic resistance.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy