Diethylcarbamazine
Diethylcarbamazine is an anthelmintic medication primarily used to treat parasitic worm infections, most notably lymphatic filariasis (caused by Wuchereria bancrofti and Brugia species) and loiasis. It is often administered in combination with other antiparasitic drugs during mass drug administration programs in endemic regions.
Anthelmintic medication used to treat lymphatic filariasis, loiasis, and tropical eosinophilia.
Key facts at a glance
- ATC
- P02CB02
- RxNorm
- 3384
- Generic
- Diethylcarbamazine
- Class
- atc-p02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of lymphatic filariasis caused by Wuchereria bancrofti, Brugia malayi, and Brugia timori; loiasis (Loa loa infection); and tropical pulmonary eosinophilia syndrome. Often used alongside albendazole or ivermectin in public health control programs.
The exact mechanism is not fully elucidated, but DEC is believed to inhibit prostaglandin synthesis and alter microfilarial membranes, making parasites more susceptible to host immune clearance. It immobilizes microfilariae and may have effects against adult worms.
Death of microfilariae can trigger inflammatory reactions including fever, headache, and malaise. Contraindicated in onchocerciasis due to risk of worsening eye disease. In loiasis patients, rapid killing of Loa loa microfilariae can cause severe encephalopathy. Should be used with caution and under medical supervision in endemic areas.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy