Difelikefalin
Difelikefalin is a kappa opioid receptor agonist used to treat moderate-to-severe pruritus (itching) in adults with chronic kidney disease (CKD) undergoing hemodialysis. It is administered intravenously during hemodialysis sessions. The medication works by targeting kappa opioid receptors to reduce itching, though the exact relationship between receptor activation and symptom relief is not fully understood.
Difelikefalin treats itching in dialysis patients by activating kappa opioid receptors.
Key facts at a glance
- ATC
- V03AX04
- RxNorm
- 2569089
- Generic
- Difelikefalin
- Class
- atc-v03a
- Brands
- Korsuva
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate-to-severe pruritus (chronic itching) in adults with chronic kidney disease who are undergoing hemodialysis.
As a kappa opioid receptor (KOR) agonist, difelikefalin activates KORs to reduce itching signals. The precise mechanism linking KOR activation to reduced pruritus is not fully characterized.
Administered as an intravenous injection three times per week at the end of hemodialysis sessions. Common side effects may include dizziness, nausea, and gastrointestinal symptoms. Safety in pregnancy and breastfeeding is not established. Patients should be monitored for potential CNS effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy