Difelikefalin Acetate
Difelikefalin acetate is a selective kappa opioid receptor agonist used to treat moderate to severe pruritus (itching) in adults with chronic kidney disease who are undergoing hemodialysis. It works by targeting kappa opioid receptors in the nervous system to help reduce itch signals and provide relief.
A kappa opioid receptor agonist used to treat itching in adults with chronic kidney disease on hemodialysis.
Key facts at a glance
- RxNorm
- 2569090
- Generic
- Difelikefalin Acetate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe chronic kidney disease-associated pruritus (CKD-aP) in adults undergoing hemodialysis.
As a selective kappa opioid receptor agonist, it binds to and activates kappa opioid receptors in the central and peripheral nervous systems, which helps reduce the transmission of itch signals and provides relief from pruritus.
Administered as an intravenous injection at the end of dialysis sessions, typically three times per week. Common side effects may include dizziness, somnolence, fatigue, and gastrointestinal symptoms. Patients should be monitored for potential adverse effects and appropriate dosing adjustments.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy