Difenoxin Hydrochloride
Difenoxin Hydrochloride is an anti-diarrheal medication that works by slowing intestinal motility and reducing fluid secretion in the gastrointestinal tract. It is typically prescribed for the symptomatic treatment of acute and chronic diarrhea, including conditions like irritable bowel syndrome with diarrhea (IBS-D).
An antidiarrheal agent that slows gut motility to provide relief from acute and chronic diarrhea.
Key facts at a glance
- RxNorm
- 235373
- Generic
- Difenoxin Hydrochloride
- Class
- pin-variant
- Brands
- Motofen
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to manage acute and chronic diarrhea, including traveler's diarrhea, IBS-D, and other conditions causing loose or watery stools when used as part of a complete treatment plan including fluid and electrolyte replacement.
Difenoxin is an opioid receptor agonist that acts primarily on the mu-opioid receptors in the intestinal wall. It inhibits peristalsis, increases intestinal transit time, and reduces intestinal secretions, allowing for firmer stools.
Contains a small amount of atropine sulfate to discourage abuse. Should not be used in patients with obstructive jaundice, toxic megacolon, or bacterial enterocolitis. May cause drowsiness; avoid operating machinery. Use with caution in patients with liver disease. Not recommended for children. Discontinue if no improvement occurs within 48 hours.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy