Fidaxomicin
Dificid (fidaxomicin) is a narrow-spectrum antibiotic specifically used to treat Clostridioides difficile (C. diff) infections, particularly in adults. It works by inhibiting bacterial RNA synthesis in the gut, targeting C. diff bacteria while having minimal impact on other intestinal flora, which may reduce recurrence rates compared to other treatments.
Dificid is a prescription antibiotic used to treat C. difficile infections in adults.
Key facts at a glance
- RxNorm
- 1111107
- Generic
- Dificid
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of Clostridioides difficile-associated diarrhea (CDAD) in adults. It is specifically indicated for initial episodes and recurrence prevention of C. diff infections.
Dificid is a macrocyclic antibiotic that works by inhibiting bacterial RNA polymerase, preventing bacterial RNA synthesis. It is minimally absorbed systemically and acts locally in the gastrointestinal tract, making it selective for C. difficile bacteria.
Take exactly as prescribed for the full 10-day course. Common side effects may include nausea, vomiting, and abdominal pain. Inform your doctor if you have any allergies or are taking other medications. Not for use in severe infections requiring systemic antibiotic coverage.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy