Diflunisal
Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, fever, and inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It works by reducing hormones that cause inflammation and pain in the body.
Diflunisal is an NSAID pain reliever and anti-inflammatory used for arthritis and moderate pain.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N02BA11
- RxNorm
- 3393
- Generic
- Diflunisal
- Class
- atc-n02
- Brands
- Dolobid
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain, osteoarthritis, rheumatoid arthritis, and fever. Particularly useful for musculoskeletal pain and inflammatory joint conditions.
Works by inhibiting cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins—chemicals responsible for pain, inflammation, and fever.
Like other NSAIDs, diflunisal carries risks of gastrointestinal bleeding, kidney impairment, and cardiovascular events. It should be avoided during late pregnancy and used cautiously in patients with a history of ulcers, kidney disease, or heart conditions. Alcohol should be avoided as it may increase stomach irritation risk.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy