Digoxin immune fab
Digifab is a brand-name medication containing digoxin-specific antibody fragments derived from sheep. It is used as an antidote to treat serious or life-threatening digoxin (Digitalis) toxicity in adults and children. The medication works by binding to digoxin molecules in the bloodstream, neutralizing their effects and allowing them to be eliminated from the body.
Digifab is an antidote medication used to treat severe digoxin toxicity by binding to and neutralizing digoxin in the bloodstream.
Key facts at a glance
- RxNorm
- 404997
- Generic
- Digifab
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Digifab is indicated for the treatment of digoxin or digitoxin toxicity, particularly in cases of potentially life-threatening overdose or poisoning. It is used when there are signs of severe cardiac toxicity such as arrhythmias, hyperkalemia, or other dangerous symptoms related to digoxin exposure.
Digifab contains fragments of antibodies that specifically bind to digoxin molecules. These Fab fragments have a high affinity for digoxin and digitoxin, binding to the drug molecules circulating in the bloodstream and tissues. Once bound, the digoxin-Fab complex is rendered inactive and is eliminated through the kidneys.
Digifab is administered intravenously by healthcare professionals in a clinical setting. Allergic reactions may occur, particularly in patients with known allergies to sheep proteins or other sheep-derived products. Serum digoxin levels may become unreliable after administration. Patients should be monitored for recurrence of toxicity and for potential hypokalemia after treatment. Digifab may interfere with standard digoxin immunoassay measurements.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy