Dihydroergotamine Mesylate
Dihydroergotamine Mesylate is an ergot alkaloid medication used primarily for the acute treatment of migraine headaches and cluster headaches. It works by constricting blood vessels and reducing inflammation associated with headache episodes. This medication is typically administered via injection, nasal spray, or oral tablets depending on the formulation.
Dihydroergotamine Mesylate is a migraine and cluster headache treatment that relieves symptoms by narrowing dilated blood vessels and blocking pain pathways.
Key facts at a glance
- RxNorm
- 203176
- Generic
- Dihydroergotamine Mesylate
- Class
- pin-variant
- Brands
- Trudhesa, Brekiya, Migranal
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Acute treatment of migraine headaches with or without aura, and cluster headache episodes. It is not intended for migraine prophylaxis or for use in patients with baseline migraine with prolonged aura.
Acts as an agonist at serotonin (5-HT1B/1D) receptors and alpha-adrenergic receptors, causing vasoconstriction of cranial blood vessels and reducing neurogenic inflammation that contributes to headache pain.
Contraindicated in patients with coronary artery disease, uncontrolled hypertension, peripheral vascular disease, or those using protease inhibitors or other potent CYP3A4 inhibitors. Should not be used within 24 hours of other ergot-containing medications or triptans. Common side effects include nausea, vomiting, and application site reactions with nasal spray formulations.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy