Dimethyl Isosorbide
Dimethyl Isosorbide is a penetration enhancer and solvent used in topical pharmaceutical and cosmetic formulations. It facilitates the delivery of active ingredients through the skin by improving absorption. While not a standalone medication for specific conditions, it serves as a vehicle component in various dermatological preparations.
A topical penetration enhancer used to improve drug delivery through the skin in various pharmaceutical formulations.
Key facts at a glance
- RxNorm
- 1426599
- Generic
- Dimethyl Isosorbide
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used as a formulation component in topical medications and cosmetics to enhance penetration of active ingredients. Commonly found in skincare products, topical analgesics, and transdermal delivery systems for various dermatological conditions.
Acts as a solubilizing agent and penetration enhancer that increases the permeability of the skin's stratum corneum, allowing active pharmaceutical ingredients to reach deeper tissue layers more effectively.
Generally regarded as safe for topical use. May cause skin irritation in sensitive individuals. Should be used as directed in formulated products. Pregnant or nursing individuals should consult a healthcare provider before using products containing this ingredient.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy