Diphenhydramine
Diphenhist is a brand-name antihistamine containing diphenhydramine that provides temporary relief from allergy symptoms such as runny nose, sneezing, and itchy eyes. It can also be used as a sleep aid and for temporary relief of cold symptoms.
Diphenhist is an antihistamine medication used to treat allergies, cold symptoms, and occasional sleeplessness.
Key facts at a glance
- RxNorm
- 216660
- Generic
- Diphenhist
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of hay fever and upper respiratory allergy symptoms including sneezing, runny nose, and itchy throat or eyes. Also used for the common cold, motion sickness prevention, and as a temporary sleep aid.
As an antihistamine, it blocks the effects of histamine, a substance in the body that causes allergic symptoms. This helps reduce or eliminate allergic reactions and associated discomfort.
May cause drowsiness; avoid alcohol and activities requiring alertness. Not recommended for children under 6 unless directed by a doctor. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications. Should not be used as a sleep aid for more than 2 weeks.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy