Diphenhydramine Citrate
Diphenhydramine Citrate is a first-generation antihistamine medication used to treat allergic reactions, seasonal allergies, and motion sickness. It also has sedative properties and is sometimes used as a sleep aid. The citrate salt form provides effective antihistamine action while being suitable for various oral formulations.
Diphenhydramine Citrate is an antihistamine used for allergies and sleep support that works by blocking histamine receptors.
Key facts at a glance
- RxNorm
- 82004
- Generic
- Diphenhydramine Citrate
- Class
- pin-variant
- Brands
- Excedrin PM Triple Action, Excedrin PM, Motrin PM
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats allergic conditions including hay fever, allergic rhinitis, and allergic skin reactions. Also used for motion sickness relief and temporary sleep difficulties.
Blocks H1 histamine receptors in the body, reducing allergic symptoms like itching, sneezing, runny nose, and hives. Crosses the blood-brain barrier, producing sedative effects.
May cause drowsiness and impaired coordination; avoid driving or operating machinery. Should not be combined with alcohol or other CNS depressants. Use with caution in elderly patients due to increased sensitivity and fall risk. Inform your doctor of any heart conditions or glaucoma before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy