Diphenhydramine Diacefyllinate
Diphenhydramine Diacefyllinate is a combination compound that pairs an antihistamine (diphenhydramine) with a xanthine derivative (diacefyllinate). This dual-action formulation potentially addresses both allergic symptoms and bronchospasm. It is typically used in patients experiencing respiratory allergies or allergic conditions with a component of airway constriction.
Combination antihistamine and bronchodilator agent for allergic conditions with respiratory symptoms.
Key facts at a glance
- RxNorm
- 236260
- Generic
- Diphenhydramine Diacefyllinate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of allergic conditions including hay fever, allergic rhinitis, and urticaria, particularly when accompanied by bronchospasm or airway sensitivity. May also be used for allergic skin reactions and as a mild sedative in some formulations.
Combines H1-receptor blockade from diphenhydramine (reducing histamine-mediated allergic responses) with bronchodilation from the diacefyllinate component (likely involving phosphodiesterase inhibition similar to other xanthine derivatives), providing relief of both allergic and respiratory symptoms.
May cause drowsiness; avoid operating machinery or driving until known. Use with caution in patients with glaucoma, urinary retention, or cardiovascular conditions. Avoid alcohol and CNS depressants. Not recommended in pregnancy or breastfeeding without medical supervision. Consult healthcare provider before use if taking other medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy